Isolation of potential liver x receptor alpha agonist and antioxidant compounds from Hypericum microcalycinum Boiss. & Heldr.
نویسندگان
چکیده
Background and Aims: Hypericum microcalycinum Boiss. & Heldr. is used for inflammatory diseases in Anatolia. The involvement of liver X receptors (LXRs) free radicals diseases, activation LXRs, high radical contents cancerous tissue organs prompted us to determine the scavenging LXRα agonist activity aqueous fraction methanol extract fractions H. along with isolation studies from active fractions. Methods: Isolation were carried out on chromatographic techniques. DPPH, NO, SO methods determination antioxidant activity, a LXRE reporter gene assay was activity. Results: While showed weak phenolic compounds- rich moderate DPPH capacities some seemed be very as well isolated compounds. Bioactivity- guided resulted catechin (1), epicatechin (2), apigenin-8-C-(2-O-acetyl)- glucopyranoside (3), quercetin-3-O-β-glucopyranoside (4), quercetin-3-O-β-arabinopyranoside (5), kaempferol-3-O-βarabinopyranoside (6), luteolin-8-C-β-glucopyranoside (orientin) (7). Conclusion: According our results, compounds 1, 2, 4, 5 may responsible anti-inflammatory effects function effects.
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ژورنال
عنوان ژورنال: Istanbul university journal of pharmacy
سال: 2021
ISSN: ['2548-0731', '2587-2087']
DOI: https://doi.org/10.26650/istanbuljpharm.2020.0066